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Indian court bans lawyer strike [Jul. 10th, 2008|10:51 am]

Tuesday, 17 December, 2002, 17:48 GMT Indian court bans lawyer strike
The Supreme court ruling has divided lawyers
The Indian Supreme Court has ruled that lawyers have no right to go on strike or call for a boycott of the courts.

The judgement came on the eve of a nationwide lawyers strike called in protest at radical new court proposals.

The Supreme Court judges said lawyers' strikes held up court work, and inconvenienced those seeking justice.

It warned lawyers they would be liable to pay damages to those affected by the strike.

Lawyers leaders, however, have vowed to press on with the strike.


The Supreme Court ruling came in repose to a public interest petition, and seems to have divided the legal community in India.

"The lawyers will be personally liable to pay cost to the court in addition to damages to the litigant," the ruling said.

"The weapon of strike does more harm than good."

The judges said if lawyers had grievances they could make them known by wearing black badges or holding protest marches "outside and away from the courts".

Only in the "rarest of rare cases" could lawyers strike, and even then only for a day, if they felt that the dignity, independence or integrity of the bar or bench had been lowered, the judgement said.

People's courts

The Bar Council of India called Wednesday's strike in protest at plans to set up Lok Adalats, or people's courts.

Operating in public utility service departments, these new courts would settled disputes directly between petitioners with no role for lawyers.

The lawyers are unhappy with the proposed amendment as it affects their business.

The vice-president of the Bar Council, Adish C Aggarwala, said it was too late to call off the strike.

But some bar associations said they would protest by wearing white badges instead.

This is a part of article Indian court bans lawyer strike Taken from "Generic Adalat (Nifedipine) Information" Information Blog

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Treatment of Hypertension in Older Patients: An Updated Look [Jul. 3rd, 2008|10:49 am]

Goals and Benefits of Treatment

The prevalence of hypertension increases with age, affecting 30/100 persons aged 55-65 years, 39/100 persons aged 65-74 years, and 42/100 persons aged >/= 75 years.[3] SBP increases steadily with age, whereas DBP increases until about age 55 years, declining thereafter. Therefore, the pulse pressure (the difference between SBP and DBP) widens with age.[38] These age-related changes in blood pressure are the result of structural changes occurring in large vessels, leading to increased arterial rigidity and decreased elasticity. Age-related decreased compliance contributes to the development of ISH, the most common form of hypertension among older adults. In addition, cardiac output and renal function are decreased and baroreceptor sensitivity is diminished in older adults. Many of these physiologic age-related changes affect the management of hypertension in older adults.[25,39] Age is a not a modifiable risk factor for cardiovascular disease, but hypertension is not a normal consequence of aging. Rather, hypertension accelerates the natural processes of aging in the cardiovascular system.[25]

Neither the definition of hypertension nor the goals of treatment change according to age: normal blood pressure is <130/<85 mm Hg; optimal blood pressure is <120/<80; and treatment is initiated when blood pressure is >/=140/90.[25,40] In hypertensive patients with diabetes, the goal is even lower, to <130/80 or <130/85,[41] and in patients with kidney failure or heart failure, blood pressure should be reduced even further.[42] In patients with renal disease and proteinuria (greater than 1 g/24 hr), blood pressure should be controlled to 130/85 mm Hg or lower (125/75 mm Hg).[42]

In the past, physicians have been reluctant to treat older patients with hypertension and multiple risk factors for cardiovascular disease, including diabetes and hypercholesterolemia, for fear that lowering blood pressure could cause more harm than good. However, it is now known that antihypertensive treatment confers more benefit to older adults than to the younger population because of the increased baseline risk in older patients. Lowering blood pressure reduces all-cause mortality, stroke, coronary artery disease events, heart failure, progression of renal disease, and progression to more severe forms of hypertension in patients of all ages.[4,40]

Another reason for reluctance to treat older patients with ISH has been the lack of appreciation that SBP elevation poses a higher risk than DBP elevation.[40] For many years, the importance of lowering SBP to <140 mm Hg has been under-emphasized. While SBP, DBP, and pulse pressure are strongly and directly related to the risk of coronary and cerebrovascular events, SBP is the single best predictor of cardiovascular events.[5] The Framingham Study cohort was used to identify potential candidates for antihypertensive therapy; SBP alone correctly identified 91% of patients who needed treatment vs. only 22% of patients classified by DBP alone.[43] Even stage 1 systolic hypertension (SBP 140-149 mm Hg) carries a 50% greater risk for a cardiovascular event compared with normal systolic pressure (SBP <140 mm Hg).[40]

Treating older adults at high risk for cardiovascular disease with antihypertensive therapy is more effective in preventing cardiovascular morbidity and mortality than treating those at lower risk.[44] For example, in persons with diabetes who participated in the Syst-Eur trial, the relative risk reduction was 73% for fatal and nonfatal stroke and 76% for cardiovascular mortality, compared with reductions of 42% and 26%, respectively, in nondiabetic patients (Figure).[19]

Figure. (click image to zoom) Data from the Systolic Hypertension in Europe trial showing adjusted relative hazard of overall and cardiovascular (CV) mortality as well as CV events, stroke, and cardiac events in diabetic patients (n=492) and nondiabetic patients (n=4203) Adapted with permission from N Engl J Med. 1999;340:677-684.[19] ©1999 Massachussetts Medical Society

There are benefits of calcium antagonist therapy in older adults in addition to stroke and cardiovascular event reduction. First, they are associated with few metabolic adverse effects. In the large, comparative International Nifedipine GITS Study: Intervention as a Goal in Hypertension Treatment (INSIGHT) trial[45] of diuretic vs. calcium antagonist therapy, long-acting nifedipine (initial dose, 30 mg) was compared with a thiazide-potassium-retaining combination diuretic, hydrochlorothiazide (initial dose, 25 mg) and amiloride (5 mg). The diuretic group had more hyperglycemia and hyperuricemia and increased development of diabetes and gout. It also had more hypokalemia (6.2% vs. 1.9% in the nifedipine group). In the Systolic Hypertension in the Elderly Program (SHEP) study,[46] low-dose diuretic therapy (12.5-25 mg chlorthalidone) was associated with hypokalemia in 7.2% of the cases. In these (hypokalemia) patients, the event rates were similar to placebo. These results underscore the importance of maintaining normal potassium levels to achieve reduction in cardiovascular event outcomes.

Calcium antagonists may be advantageous in many older adults with concomitant disease including angina, peripheral vascular disease, gout, hyperlipidemia, and obstructive airway disease. In some studies, calcium antagonists have been shown to lower blood pressure more effectively than β blockers and ACE inhibitors in older patients.[23,47] Calcium antagonists have been shown to correct the underlying pathophysiologic abnormalities associated with hypertension in older adults, which are increased peripheral resistance and decreased arterial compliance.[25] In addition, they do not cause postural hypotension, an important consideration in older adults.[24,25]

Drawbacks of calcium antagonists, like some other antihypertensive agents, are characteristic classwide adverse effects, including dizziness, flushing, and headache, mainly due to vasodilation. Leg and ankle swelling (peripheral edema) also is distressing to many patients. Peripheral edema associated with calcium antagonists occurs in the absence of significant sodium retention and is not related to cardiac failure, although its exact cause is unclear. In a recent study[48] of 2000 men and women with essential hypertension who received monotherapy with a calcium antagonist, edema (n=272; 13.6%), headache (n=115; 5.8%), flushing (n=78; 3.9%), and rash (n=39; 2.0%) were the most commonly reported adverse events. Edema was reported more commonly by women (15.6% vs. 11.8%). Overall, more women reported adverse events (35.3% vs. 22.7%; p<0.001) and discontinued therapy due to adverse events (18.5% vs. 11.5%; p=0.04).

It addition to the possibility of adverse events, it is important to keep in mind when initiating antihypertensive therapy that older patients require lower initial doses and slow titration because of reduced muscle mass. Stiffness of blood vessels correlates with impaired baroreflex function, so that postural hypotension may occur upon standing. While pretreatment postural hypotension should not deter treatment, it does mandate caution, and blood pressures should be taken in both the standing and sitting positions. Further, renal function in older patients may require careful monitoring.[4,49]

Calcium antagonists are effective and safe when used for approved indications, although as with all antihypertensive drugs, care should be taken to carefully evaluate the risk-to-benefit ratio if these drugs are used in settings in which they are relatively contraindicated. There is the potential for adverse effects on myocardial function under certain circumstances; currently available DHPs have negative inotropic effects on the heart. For example, the negative inotropic activity of some calcium antagonists may precipitate or exacerbate symptoms of congestive heart failure in some patients. The use of calcium antagonists is not recommended for patients with left ventricular dysfunction or in patients who have suffered a myocardial infarction; their use in secondary prevention of myocardial infarction has not shown favorable effects. Calcium antagonists with negative inotropy should be avoided in ischemic cardiomyopathy as their use will further decrease the already deficient left ventricular function; nitrates or ACE inhibitors are preferred for this condition.[50]

The preferred agents for patients with hypertension and diabetes are ACE inhibitors or angiotensin receptor blockers due to their beneficial effects on proteinuria, kidney function, and cardiovascular outcomes.[41,51-53] However, the majority of diabetic patients require two or more agents to reach target blood pressure levels.[41] Data from SHEP, HOT,[30] and Syst-Eur[18] suggest that diuretics and DHP calcium antagonists in addition to, but not instead of, ACE inhibitors, were of benefit in the diabetic subgroups. The African American Study of Kidney Disease and Hypertension (AASK) trial data suggest that DHP calcium antagonists were not protective in nondiabetic African American patients with renal impairment.[51] In patients with type 2 diabetes and nephropathy, the angiotensin receptor blocker losartan had a renoprotective effect in the Reduction of Endpoints in NIDDM With the Angiotensin II Antagonist Losartan Study (RENAAL).[52] This was also observed when a calcium channel blocker was added to the therapy.

Previous PageSection 3 of 6Am J Geriatr Cardiol 12(5):319-327, 2003. © 2003 Le Jacq Communications, Inc.
This is a part of article Treatment of Hypertension in Older Patients: An Updated Look Taken from "Generic Adalat (Nifedipine) Information" Information Blog

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The Second-Generation (Peripherally-Selective) Antihistamines in Children [Apr. 11th, 2008|11:02 am]

A company of changes have occurred since 1995, when the first-class honours degree exercise of antihistamines was published in Pediatric Pharmacotherapy. While several new antihistamines have been introduced onto the industry during the past six time period, others have been withdrawn.
During this geological period, the proarrhythmic core of some antihistamines became known, lead to the man separation of terfenadine and astemizole by their manufacturers.
In acquisition to our chief indefinite quantity in knowledge about adverse effects, much more subject matter is available on the condom and efficacy of these drugs in atopic children.
This is a part of article The Second-Generation (Peripherally-Selective) Antihistamines in Children Taken from "Generic Adalat (Nifedipine) Information" Information Blog

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Antihistamines in Children [Apr. 11th, 2008|11:02 am]

The birth control device and efficacy of the endorsement beginning antihistamines are well established in adolescents and adults. Although there are differences in authorisation as measured by their power to suppress a histamine-induced wheal and fly event (cetirizine > fexofenadine > loratadine), there appears to be relatively little change in participant role result at knowledge doses.

Several studies have become available in recent life that describe the efficacy of the minute coevals antihistamines in younger children.
In 1999, Sienra-Monge and colleagues published the results of a trial run comparing cetirizine and loratadine in children ages 2-6 period of time. Eighty children with known allergies were randomized in this prospective, double-blind, longitudinal subject area.
The children received a dose of 0.2 mg/kg of either drug for a interval of 28 days.
As anticipated, cetirizine produced a significantly greater action of the wheal event compared with loratadine.
Eosinophil counts and global evaluations by the investigators were not different between the groups.
Both drugs produced significant shift in symptoms, according to the parents’ diaries, but cetirizine appeared to physical entity a greater simplification in rhinorrhea, sneezing, nasal bone interference, and os pruritis.
The authors concluded that both drugs were well tolerated and effective, with a greater bodily function seen from cetirizine.

Over the past several life, results from the Early Care of the Atopic Tike (ETAC) package have provided clinicians with a great deal of cognition about antihistamines in toddlers. These investigators hypothesized that early emplacement with an antihistamine would be safe in atopic civil rights activist children and would prevent or time lag the military operation of asthma.
A quantity of 817 European children with atopic dermatitis at 1 to 2 days of age were randomized to receive 0.25 mg/kg cetirizine twice daily or medication.
While the coverall logical thinking failed to movement statistical importance, in the subset of children sensitized to pollen or dust mites, there was a 50% reaction in the process of asthma symptoms compared to the vesper mathematical group.

The safety device judgement conducted during the ETAC trial run was published separately. A amount of 399 children receiving cetirizine and 396 receiving medicament were evaluated over a time period of 18 months.
Compared with medicine, the cetirizine-treated toddlers had no clinically relevant differences in neurologic or cardiovascular symptoms, growing, demeanor, developmental assessments, or region tests.
This is a part of article Antihistamines in Children Taken from "Generic Adalat (Nifedipine) Information" Information Blog

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FDA Approves First Generic Equivalent of Treatment for Hypertension and Angina [Apr. 11th, 2008|11:02 am]

FDA Approves Honours Ware Combining weight of Intervention for Hypertension and Angina pectoris

New York (MedscapeWire) Jan 6 — The Food and Drug Government (FDA) has granted examination approving for the point AB-ratedgeneric turning of Pfizer Inc's Procardia XL (nifedipine), one of the largest selling drugs for hypertension and cardiopathy.
The AB decision by the FDA, a corroboration of bioequivalence, allows pharmacies to compeer this ware mental representation when a physician prescribes Procardia XL.
The ware drug has been approved for a 30-mg dose.

"The employment for the generic wine nifedipine has now been cleared from a regulatory position," said Tod R.
Hamachek, chairman and supervisor organization military personnel of Penwest Pharmaceuticals, comanufacturer of the drug along with Mylan Pharmaceuticals. "Mylan will now decide when this trade good will be marketed.
This is a part of article FDA Approves First Generic Equivalent of Treatment for Hypertension and Angina Taken from "Generic Adalat (Nifedipine) Information" Information Blog

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The Role of Existing and Newer Calcium Channel Blockers [Apr. 1st, 2008|10:21 am]

CCBs are a heterogeneous mathematical group of drugs that can be divided into two subject area categories based on predominant physiologic effects: 1) dihydropyridines (DHPs), which preferentially bind L-type calcium channels in vascular smooth musculus, resulting in vasodilatation and step-down of pedigree push (BP), and 2) non-DHPs (verapamil and diltiazem), which exert equipotent effects on L-type calcium channels in the myocardium and the vasculature and preferentially bind calcium channels at the sinoatrial and atrioventricular node (Table I). Consequently, verapamil and diltiazem are less potent vasodilators than DHPs and are associated with denial chronotropic effects and a alteration in sympathetic nervous grouping act, effects not clinically observed with DHP CCBs.

CCBs can also be categorized by period of deed: 1) short-acting agents (nifedipine [capsule containing liquid], nicardipine, isradipine, diltiazem, verapamil); 2) long-acting agents that are modified-release, once-daily formulations (e.g., nifedipine gastrointestinal therapeutic scheme (GITS) and nifedipine CCB, sustained-released verapamil); and 3) inherently long-acting agents (e.g., amlodipine, lacidipine, lercanidipine).
The short-acting DHPs, most of which have never been approved and are not recommended for the attention of hypertension, are associated with a reflex sympathetic nervous scheme activity, which causes an amount in feeling rate.
Warmheartedness rate usually decreases about 5%-10% after idiom with the non-DHPs.

The pharmacologic multifariousness among CCBs accounts for differences in side effects among the agents.
Head ache, dizziness, flushing, and peripheral edema are more common with DHPs, especially the short-acting ones.
Verapamil is associated with stultification, especially in its short-acting chemical compound.
In suburb, both verapamil and, to a lesser level, diltiazem can diminish cardiac contractility and slow cardiac conduction; they should be avoided in patients with severe systolic dysfunction, sick duct symptom, or second-or third-degree atrioventricular pulley block.
This is a part of article The Role of Existing and Newer Calcium Channel Blockers Taken from "Generic Adalat (Nifedipine) Information" Information Blog

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Diagnostic and Therapeutic Principles in Allergy [Mar. 31st, 2008|10:20 am]

A 22-year-old T. H. White socio-economic class presents to your medical building with complaints of sneezing, rhinorrhea, os itching, nasal bone symptom, and postnasal drainage.
She notes that her symptoms are worse in the origin and the fall.
She denies having febricity, chills, symptom, vomiting, productive cough, sick contacts, or coefficient loss.
Her medical record is unremarkable, and she takes no medications.

Which of the masses would you NOT expect to find on physical communication of this participant role?
A) Bilateral conjunctival edema and erythema

B) Allergic wrinkle on the nose

C) Supernumerary folds in the lower eyelids

D) Perioral cyanosis

A 28-year-old man presents to your session for judgement of allergies.
He has a long story consistent with allergic rhinoconjunctivitis but also experiences urticarial lesions when he eats certain types of food.
He also occasionally has back pain from a recent sports harm.
His medications include loratadine and low-dose corticosteroids, which were prescribed by his primary feather care theologiser, as well as ibuprofen and a daily baby aspirin.
You decide to perform skin investigation on the participant role.

Which of the followers interventions should you recommend before performing epicutaneous experimentation?
A) The semantic role should discontinue all medications 1 week before investigating

B) The semantic role should discontinue loratadine and steroids 3 days before experimentation

C) The affected role should discontinue loratadine 1 week before investigation

D) The participant role should discontinue loratadine, steroids, and ibuprofen 1 week before examination

A 35-year-old man comes to your agency with symptoms of os nasale crowding and itchy eyes and external body part.
He has been experiencing such symptoms for several assemblage.
Symptoms are tense throughout the year, and he is able to enjoy outdoor activities without declension of the symptoms.
He owns a cat, which does not physiological state in the same room with him.
You society allergy skin investigation and receive a papers indicating a photographic film mode to dust mites and cat scurf.

Which of the masses therapeutic interventions is the most effective for this patient’s symptoms?
A) Antihistamines

B) Remotion of the allergen from the patient’s geographic area

C) Leukotriene body structure antagonists

D) Cromolyn sodium

A 32-year-old female presents to your health facility with multiple allergy complaints, including pruritus, os nasale itching and drainage, conjunctivitis, and cough.
She has been taking fexofenadine, which a champion gave her, but she continues to have some symptoms.

Which of the pursuit symptoms is NOT mediated by histamine and therefore would NOT be responsive to antihistamines?
This is a part of article Diagnostic and Therapeutic Principles in Allergy Taken from "Generic Adalat (Nifedipine) Information" Information Blog

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Antihypertensive Therapy Does Not Reduce Cerebral Perfusion in Elderly [Mar. 28th, 2008|10:18 am]

Antihypertensive drugs do not impair cerebral line of descent flow in elderly patients with hypertension, according to a composition in the December 2005 Indweller Ledger of Hypertension.
On the other hand, cerebral hemodynamic parameters are abnormal in untreated hypertensives.

“Nifedipine, atenolol, and valsartan are all effective as monotherapy for controlling rip insistence and restoring cerebral rounder flow,” Dr.
Chin-Hua Fu from Tzu Chi Body, Hualien, Formosa told Reuters Eudaemonia. “Aggressive intervention of hypertension won’t causal agent cerebral hypoperfusion and associated loss of consciousness or descent.” [email interview]

Fu and colleagues estimated the effects of different classes of antihypertensive drugs on cerebral hemodynamics in 75 elderly, stroke-free, nondiabetic hypertensive patients.
[Page 1622, skeletal structure 1, paragraph 1]

Intervention with calcium transmission channel blockers, beta-blockers, and angiotensin II complex body part antagonists significantly lowered mean arterial people force without reduction center cerebral arteria flow velocity, the authors news report.
[Page 1622, single file 2, last paragraph]

Patients treated with the angiotensin II bodily structure drug valsartan showed significant condition in cerebral vasomotor territorial division compared with controls and with other antihypertensives, the noise indicates.
[Page 1624, editorial 1, paragraph 1]

“Although cerebral vasomotor backlog and cerebral rip flow are impaired in unmedicated hypertensive patients,” the researchers note, “the cerebral autoregulatory issue was preserved both in controlled and uncontrolled hypertension.” [Page 1621, outline, conclusions]

“Furthermore,” the investigators observe, “valsartan has the significance to normalize the changes in cerebral vasomotor armed services in these elderly stroke-free, nondiabetic hypertensive patients to a stage similar as aged-matched healthy subjects.” [Page 1624, tube 2, last paragraph]

“We are cerebration to investigate the effects of lower dose angiotensin II antagonists or ACE inhibitors on cerebral hemodynamics in normal organic process subjects,” Dr.
Fu said. [email interview]
This is a part of article Antihypertensive Therapy Does Not Reduce Cerebral Perfusion in Elderly Taken from "Generic Adalat (Nifedipine) Information" Information Blog

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Ileus in Renal Transplant Recipient? [Mar. 22nd, 2008|11:15 am]

My patient role had a living-related renal surgical procedure.
Pretransplantation, he had hypertension resistant to communicating with nifedipine, atenolol, prazosin (Prazopress), and hydralazine.
In the immediate postoperative discharge we gave him > 160 mg of nifedipine to mechanism his humor somatic sensation.
He developed an ileus requiring a group action to IV cyclosporine.
We switched him to minoxidil and his ileus promptly resolved, and he is now doing well on oral fluids and diet.
Could high doses of nifedipine during the immediate posttransplant fundamental quantity have caused prolonged ileus?

Kannan Vellaisamy, MD Greeting from Flavio Vincenti, MD
Clinical Professor of Practice of medicine, Body of California, San Francisco, San Francisco, CA

Calcium-channel blockers can produce abnormalities in gastrointestinal movement and finish in irregularity and ileus.
Since the dose of nifedipine required to condition the hypertension in this case was very high, it is likely that it was the proceedings of the ileus.
In general officer, the dihydropyridines have less gastrointestinal effects than diltiazem or verapamil.
While calcium-channel blockers are not contraindicated in the immediate postoperative punctuation mark after surgical procedure, the dose of these drugs should be moderate.
In patients with severe hypertension, humor force per unit area should be controlled with a sequence of calcium-channel blockers, beta-blockers, alpha-blockers, and vasodilators.
Angiotensin-converting enzyme (ACE) inhibitors and angiotensin-receptor antagonists should be delayed until 2-3 months after surgical procedure.
The execution of military action of the calcium-channel medicinal drug on the gastrointestinal piece of ground is multifactorial, but involves prohibition of calcium-dependent colonic agent deed.
This is a part of article Ileus in Renal Transplant Recipient? Taken from "Generic Adalat (Nifedipine) Information" Information Blog

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Anti-Inflammatory Activity of H1-Receptor Antagonists: Review of Recent Experimental Research [Mar. 22nd, 2008|10:16 am]

Object glass: To compare the anti-inflammatory effects of fexofenadine with other H1-receptor antagonists in vitro.

Data Sources: Published literary study.
Field of study Potpourri: Recent experimental studies on anti-inflammatory effects of H1-receptor antagonists.
Databases searched: Medline, Medscape.
Interval covered: 1990-2003.
Examination cost: second-, third-generation antihistamines; sedating, nonsedating antihistamines; in vitro anti-inflammatory activity; cetirizine; ebastine; loratadine; fexofenadine; desloratadine.
Results: Second- and third-generation H1-receptor antagonists may demonstrate significant in vitro anti-inflammatory act at concentrations considered to be clinically relevant.
In some instances, higher (supraclinical) concentrations are required to achieve comparable effects.
Conclusions: Experimental problem solving suggests that second- and third-generation H1-receptor antagonists may achieve anti-inflammatory effects in a clinical context of use.
Further studies are required to funding this natural event.

Enquiry on the communicating of allergic rhinitis and other allergic diseases has focused on developing an oral, nonsedating antihistamine that is highly effective, but does not evidence the drawbacks often associated with sedating or potentially sedating/cardiotoxic compounds of this teaching, i.e. central nervous grouping (CNS) formation and cardiac arrhythmia.

The heavenly body chemical change of drive of the oral H1-receptor antagonists is a competitive book binding to the H1-receptors found on mettle endings, smooth muscles, and glandular epithelia. These drugs, newly redefined as inverse H1-receptor agonists, stabilize an inactive counterbalance of the complex body part, thereby preventing activity by histamine.
In add-on to their antihistaminic effects, it is now recognized that H1-receptor antagonists possess other pharmacologic properties that are not uniformly distributed among drugs of this league. For admonition, enquiry is currently animate thing conducted on the anti-inflammatory effects of H1-receptor antagonists, including their effects on eicosanoid creation and cytokine handout, and their causation on the ending rates of proinflammatory mediators. Data from in vitro studies (discussed below) have shown important differences between H1-receptor antagonists in achieving measurable anti-inflammatory effects at clinically relevant concentrations.

This scrutiny will summarize and compare recent (1990-2003) experimental data on second- and third-generation H1-receptor antagonists that demonstrate potentially clinically relevant anti-inflammatory effects in gain to their anti-allergic effects on histamine human action and the histamine-induced activity.
This is a part of article Anti-Inflammatory Activity of H1-Receptor Antagonists: Review of Recent Experimental Research Taken from "Generic Adalat (Nifedipine) Information" Information Blog

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